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TAU PROTEINS
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DeCS
Descriptor
English
:
tau Proteins
Descriptor
Spanish
:
Proteínas tau
Descriptor
Portuguese
:
Proteínas tau
Synonyms
English
:
Protein, tau
Proteins, tau
tau Protein
Tree Number:
D12.776.220.600.450.510
D12.776.631.560.510
Definition
English
:
Microtubule-associated proteins
that are mainly expressed in
neurons
.
Tau proteins
constitute several isoforms and play an important role in the assembly of
tubulin
monomers into
microtubules
and in maintaining the
cytoskeleton
and
axonal transport
. Aggregation of specific sets of
tau proteins
in filamentous inclusions is the common feature of intraneuronal and glial fibrillar lesions (
NEUROFIBRILLARY TANGLES
;
NEUROPIL THREADS
) in numerous neurodegenerative disorders (
ALZHEIMER DISEASE
;
TAUOPATHIES
).
See Related
English
:
Tauopathies
History Note
English
:
1992; use TAU (NM) 1977-91
Allowable Qualifiers
English
:
AD
administration & dosage
AE
adverse effects
AG
agonists
AN
analysis
AI
antagonists & inhibitors
BI
biosynthesis
BL
blood
CF
cerebrospinal fluid
CS
chemical synthesis
CH
chemistry
CL
classification
DF
deficiency
DE
drug effects
EC
economics
GE
genetics
HI
history
IM
immunology
IP
isolation & purification
ME
metabolism
PK
pharmacokinetics
PD
pharmacology
PH
physiology
PO
poisoning
RE
radiation effects
ST
standards
SD
supply & distribution
TU
therapeutic use
TO
toxicity
UL
ultrastructure
UR
urine
Record Number:
30290
Unique Identifier:
D016875
Occurrence in VHL
:
Similar:
DeCS